Rabbit Anti-Laminin B2 gamma 1/AF350 Conjugated antibody
LAMB 2; LAMB2; LAMC 1; LAMC1; LAMC1_HUMAN; Laminin B2 chain; Laminin gamma 1; Laminin gamma 1 chain; MGC87297.
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Product Name Anti-Laminin B2 gamma 1/AF350 Chinese Name AF350标记的层粘连蛋白B2γ1抗体 Alias LAMB 2; LAMB2; LAMC 1; LAMC1; LAMC1_HUMAN; Laminin B2 chain; Laminin gamma 1; Laminin gamma 1 chain; MGC87297. Research Area Cardiovascular Cell biology immunology Signal transduction Cytoskeleton Extracellular matrix Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Cow, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 174kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Laminin B2 gamma 1 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes.
Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subunit:
Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2 (laminin-211 or merosin), laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-6 (laminin-311 or K-laminin), laminin-7 (laminin-321 or KS-laminin), laminin-8 (laminin-411), laminin-9 (laminin-421), laminin-10 (laminin-511) and laminin-11 (laminin-521).
Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane.
Tissue Specificity:
Found in the basement membranes.
Similarity:
Contains 11 laminin EGF-like domains.
Contains 1 laminin IV type A domain.
Contains 1 laminin N-terminal domain.
Database links:Entrez Gene: 3915 Human
Entrez Gene: 226519 Mouse
Omim: 150290 Human
SwissProt: P11047 Human
SwissProt: Q5VYE7 Human
SwissProt: Q6NVY8 Human
SwissProt: P02468 Mouse
Unigene: 609663 Human
Unigene: 1249 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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| Username | Quantity | bought time |
| We*** | 2 | 2024-01-08 |
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