Product Name	Mouse Anti-Rabbit IgM / AF488
Chinese Name	Alexa Fluor 488标记的小鼠抗兔IgM
Alias	Mouse Anti-Rabbit IgM (Alexa Fluor® 488); Immunoglobulin M;
	Specific References  (4)     |     SL0369M-AF488 has been referenced in 4 publications. [IF=14.976] Junli Zhang. et al. Localized fluorescent imaging of multiple proteins on individual extracellular vesicles using rolling circle amplification for cancer diagnosis. J Extracell Vesicles. 2020 Nov;10(1):e12025   PubMed:33304477 [IF=7.376] Li-Ming Yu. et al. Activation of PKG-CREB-KLF15 by melatonin attenuates Angiotensin II-induced vulnerability to atrial fibrillation via enhancing branched-chain amino acids catabolism. Free Radical Bio Med. 2021 Dec;:  IF ;  Mouse.   PubMed:34864165 [IF=2.985] Xiaohan Yuanet al. NCOA5 is a master regulator of amino acid-induced mTOR activation and β-casein synthesis in bovine mammary epithelial cells. Biochem Biophys Res Commun . 2020 Aug 27;529(3):569-574.  IF ;  cow.   PubMed:32736675 [IF=2.47] Li, Lu, et al. "Twinfilin 1 enhances milk bio-synthesis and proliferation of bovine mammary epithelial cells via the mTOR signaling pathway." Biochemical and Biophysical Research Communications (2017).  IF(ICC) ;  Rabbit.   PubMed:28864421
Immunogen Species	Mouse
Clonality	Polyclonal
React Species	Rabbit,
Applications	Flow-Cyt=1:100-1000 IF=1:100-1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Form	Liquid
Concentration	2.0 mg/ml
immunogen	Native Rabbit IgM
Lsotype	IgG
Purification	affinity purified by Protein G
Buffer Solution	10 mM TBS (pH=7.4) with 1% BSA, 0.03% Proclin300 and 50% glycerol.
Storage	Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Product Detail	Immunoglobulin M (IgM) normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences.

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