Product Name	Goat Anti-Mouse IgM / AF555
Chinese Name	Alexa Fluor 555标记的羊抗小鼠IgM
Alias	Goat Anti-Mouse IgM (Alexa Fluor® 555); Immunoglobulin M;
	Specific References  (4)     |     SL0368G-AF555 has been referenced in 4 publications. [IF=5.561] Weijie Zhao. et al. Mannan Oligosaccharides Promoted Skeletal Muscle Hypertrophy through the Gut Microbiome and Microbial Metabolites in Mice. FOODS. 2023 Jan;12(2):357  ICC ;  Mouse.   PubMed:36673449 [IF=5.279] Chen Duan. et al. trans 10, cis 12, but Not cis 9, trans 11 Conjugated Linoleic Acid Isomer Enhances Exercise Endurance by Increasing Oxidative Skeletal Muscle Fiber Type via Toll-like Receptor 4 Signaling in Mice. J Agr Food Chem. 2021;69(51):15636–15648  IF ;  Mouse.   PubMed:34928153 [IF=4.966] Fan Li. et al. PHD3 mediates denervation skeletal muscle atrophy through Nf‐κB signal pathway. Faseb J. 2021 Apr;35(4):e21444  IF,FC ;  Mouse.   PubMed:33749901 [IF=2.903] Jiang C et al. Nrf2/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation. Cell Stress Chaperones. 2020 May;25(3):395-406.  IF ;  human.   PubMed:32124251
Immunogen Species	Goat
Clonality	Polyclonal
React Species	Mouse,
Applications	IF=1:100-1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Form	Liquid
Concentration	2.0 mg/ml
immunogen	Native Mouse IgM
Lsotype	IgG
Purification	affinity purified by Protein G
Buffer Solution	10 mM TBS (pH=7.4) with 1% BSA, 0.03% Proclin300 and 50% glycerol.
Storage	Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Product Detail	Immunoglobulin M (IgM) normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences.

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