Product Name	Rabbit Anti-Rat IgM / HRP
Chinese Name	辣根过氧化物酶标记的兔抗大鼠IgM
Alias	Rabbit Anti-Rat IgM (HRP); Immunoglobulin M;
	Specific References  (3)     |     SL0346R-HRP has been referenced in 3 publications. [IF=5.116] Chunyu Jiang. et al. Upregulating CXCR7 accelerates endothelial progenitor cell-mediated endothelial repair by activating Akt/Keap-1/Nrf2 signaling in diabetes mellitus. Stem Cell Res Ther. 2021 Dec;12(1):1-15  WB ;  Rat.   PubMed:33941256 [IF=2.784] Guo X et al.RP105 ameliorates hypoxia̸reoxygenation injury in cardiac microvascular endothelial cells by suppressing TLR4̸MAPKs̸NF-κB signaling.Int J Mol Med. 2018 Jul;42(1):505-513.  WB ;  Rat.   PubMed:29693119 [IF=0.46] Su, Yuqing, et al. "Mixed PEGylated surfactant modifying system decrease the accelerated blood clearance phenomenon of nanoemulsions in rats."Asian Journal of Pharmaceutical Sciences (2016).  ELISA ;  Rat.   PubMed:10.1016/j.ajps.2016.07.003
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,
Applications	WB=1:1000-10000 ELISA=1:1000-10000 IHC-P=1:100-1000 IHC-F=1:100-1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Form	Liquid
Concentration	2.0 mg/ml
immunogen	Native Rat IgM
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	10 mM TBS (pH=7.4) with 1% BSA, 0.03% Proclin300 and 50% glycerol.
Storage	Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Product Detail	IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences.

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