Product Name	Goat Anti-Mouse IgG H&L / AF488
Chinese Name	Alexa Fluor 488标记的羊抗小鼠IgG H&L
Alias	Goat Anti-Mouse IgG H&L (Alexa Fluor® 488); Immunoglobulin G;
	Specific References  (26)     |     SL0296G-AF488 has been referenced in 26 publications. [IF=16.874] Zhenglong Dou. et al. A “built-up” composite film with synergistic functionalities on Mg–2Zn–1Mn bioresorbable stents improves corrosion control effects and biocompatibility. BIOACT MATER. 2023 Jul;25:223  IHC ;  Rabbit.   PubMed:36817823 [IF=13.352] Yu-Ting Zhou. et al. Perfluorooctanoic acid (PFOA) exposure affects early embryonic development and offspring oocyte quality via inducing mitochondrial dysfunction. ENVIRON INT. 2022 Sep;167:107413  IF ;  Mouse.   PubMed:35863238 [IF=13.281] Ximu Zhang. et al. A Bioinspired Hemostatic Powder Derived from the Skin Secretion of Andrias davidianus for Rapid Hemostasis and Intraoral Wound Healing. 2021 Nov 23  IHC ;  Rat.   PubMed:34817129 [IF=10.383] Qingfei Zhang. et al. Hierarchical Microparticles Delivering Oxaliplatin and NLG919 Nanoprodrugs for Local Chemo-immunotherapy. ACS APPL MATER INTER. 2022;XXXX(XXX):XXX-XXX  IF ;  Mouse.   PubMed:36263713 [IF=8.079] Yuan, Yu. et al. Adipose-derived stromal/stem cells are verified to be potential seed candidates for bio-root regeneration in three-dimensional culture. STEM CELL RES THER. 2022 Dec;13(1):1-23  IF ;  Human.   PubMed:35659736 [IF=7.666] Yan Liu. et al. S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression. CELLS-BASEL. 2022 Jan;11(22):3579  IF ;  Human, Mouse.   PubMed:36429008 [IF=7.217] Jing Wang. et al. Dopamine D3 Receptor in the Nucleus Accumbens Alleviates Neuroinflammation in a Mouse Model of Depressive-Like Behavior. Brain Behav Immun. 2021 Dec;:  IF ;  Mouse.   PubMed:34971757 [IF=6.78] Ning Zhang. et al. Spatial transcriptomics shows moxibustion promotes hippocampus astrocyte and neuron interaction. LIFE SCI. 2022 Oct;:121052  IF ;  Mouse.   PubMed:36220370 [IF=6.633] Yu Cui. et al. ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation. Brain Behav Immun. 2021 Jan;:  IF,IHC ;  Mouse.   PubMed:33444733 [IF=6.022] Fan Y et al. A function of fascin1 in the colony formation of Mouseembryonic stem cells. Stem Cells. 2020 Sep;38(9):1078-1090.  ICF ;  Mouse.   PubMed:32379912 [IF=5.81] Yingyu Lu. et al. Combined Administration of Vitamin D3 and Geniposide Is Less Effective than Single Use of Vitamin D3 or Geniposide in the Treatment of Ulcerative Colitis. Front Pharmacol. 2021; 12: 714065  WB ;  Mouse.   PubMed:34650431 [IF=5.7] Zhang XY et al. KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke. Journal of Neuroinflammation.2019.  IHF-F ;  Mouse.   PubMed:doi:10.21203/rs.2.18352/v1 [IF=5.5] Sun J et al. LncRNA Expression Profile of Human Thoracic Aortic Dissection by High-Throughput Sequencing.Cell Physiol Biochem. 2018;46(3):1027-1041.  FCM ;  Mouse.   PubMed:29669321 [IF=5.285] Chaochao Luo. et al. Sodium acetate promotes fat synthesis by suppressing TATA element modulatory factor 1 in bovine mammary epithelial cells. ANIM NUTR. 2023 Jan;:  IF ;  Bovine.   PubMed:10.1016/j.aninu.2023.01.002 [IF=5.005] Jiahui An. et al. Pili Subunit PilA Contributes to the Cytoadhesion of Glaesserella Parasuis to Host Cells and Provides Immunoprotection. APPL ENVIRON MICROB. 2023 Mar 15  FCM ;  Glaesserella parasuis.   PubMed:36920203 [IF=4.925] Yuan P et al. The nanomaterial-induced bystander effects reprogrammed macrophage immune function and metabolic profile. Nanotoxicology . 2020 Oct;14(8):1137-1155.  ICF ;  Mouse.   PubMed:32916084 [IF=4.925]  Peng Yuan . et al. The nanomaterial-induced bystander effects reprogrammed macrophage immune function and metabolic profile. Nanotoxicology. 2020;14(8):1137-1155  IF ;  Human.   PubMed:32916084 [IF=3.976] Ma Zheng. et al. miR-6315 silencing protects against spinal cord injury through the Smo and anti-ferroptosis pathway. BIOSCIENCE REP. 2023 Mar;:  IF ;  Rat.   PubMed:36946310 [IF=3.231] Yufang Ge. et al. Natural Evolution of Porcine Epidemic Diarrhea Viruses Isolated from Maternally Immunized Piglets. ANIMALS. 2023 Jan;13(11):1766  ICC ;  Monkey.   PubMed:10.3390/ani13111766 [IF=2.736] Zhou Z et al. Swine acute diarrhea syndrome coronavirus (SADS-CoV) antagonizes interferon-β production via blocking IPS-1 and RIG-I. Virus Res. 2019 Dec 26;278:197843.  ICF ;  Mouse.   PubMed:31884203 [IF=2.216] Ding,et al.Porphyromonas gingivalis, a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice.(2018) Immunity & Ageing. 15:6.  IHC-P ;  Mouse.   PubMed:29422938 [IF=2.107] Chen X et al. Ginsenoside compound K ameliorates Alzheimer's disease in HT22 cells by adjusting energy metabolism. Mol Biol Rep. 2019 Jul 30.  ICF ;  Mouse.   PubMed:31364016 [IF=2.1] Bing Li. et al. miR‑449a‑5p suppresses CDK6 expression to inhibit cardiomyocyte proliferation. Mol Med Rep. 2021 Jan;23(1):1-1  IF ;  Mouse.   PubMed:33179102 [IF=1.831] Chen,et al.Mitochondrial ATAD3A regulates milk biosynthesis and proliferation of mammary epithelial cells from dairy cow via the mTOR pathway.(2018) Cell Biology International. 42:533-542.  IF(ICC) ;  Mouse.   PubMed:29286187 [IF=1.587] Weiqi Feng. et al. Generation of an induced pluripotent stem cell line from an aortic dissection patient carrying MCTP2/c.2635T > G mutation. STEM CELL RES. 2023 Apr;68:103058  IF ;  Human.   PubMed:36868039 [IF=0] Gong, Tao, et al. "The Control of Mesenchymal Stem Cell Differentiation Using Dynamically Tunable Surface Microgrooves." Advanced Healthcare Materials (2014).  Mouse.   PubMed:24648133
Immunogen Species	Goat
Clonality	Polyclonal
React Species	Mouse,
Applications	Flow-Cyt=1:100-1000 IF=1:100-1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Form	Liquid
Concentration	2.0 mg/ml
immunogen	Native Mouse IgG
Lsotype	IgG
Purification	affinity purified by Protein G, nonspecific adsorbed
Buffer Solution	10 mM TBS (pH=7.4) with 1% BSA, 0.03% Proclin300 and 50% glycerol.
Storage	Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Product Detail	Immunoglobulin G (IgG), is one of the most abundant proteins in serum with normal levels between 8-17 mg/mL in adult blood. IgG is important for our defence against microorganisms and the molecules are produced by B lymphocytes as a part of our adaptive immune response. The IgG molecule has two separate functions; to bind to the pathogen that elicited the response and to recruit other cells and molecules to destroy the antigen. The variability of the IgG pool is generated by somatic recombination and the number of specificities in an individual at a given time point is estimated to be 1011 variants.

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