Product Name	SIRT6
Chinese Name	沉默调节相关蛋白6Recombinant rabbit monoclonal anti
Alias	NAD-dependent protein deacylase sirtuin-6; SIR2L6; EC:2.3.1.-; NAD-dependent protein deacetylase sirtuin-6; Protein mono-ADP-ribosyltransferase sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2-like protein 6;
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	R4G8
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:200-1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	39kDa
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SIRT6
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016] Subcellular Location: Nucleus, nucleoplasm. SWISS: Q8N6T7 Gene ID: 51548 Database links: Entrez Gene: 51548 Human Entrez Gene: 50721 Mouse Entrez Gene: 299638 Rat SwissProt: Q8N6T7 Human SwissProt: P59941 Mouse
Product Picture	Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:1000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: 1: HCT-116, 2: HeLa, 3: Jurkat, 4: C2C12, 5: PC-12 Protein loading quantity: 20 μg Exposure time: 60 s Predicted MW: 39 kDa Observed MW: 42 kDa Tissue: Human esophagus Section type: Formalin-fixed & Paraffin embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1:1000 Primary Ab incubation condition: 1 hour at room temperature Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to use) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-52556R

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