Product Name	FOXP1
Chinese Name	叉头蛋白P1Recombinant rabbit monoclonal anti
Alias	FLJ23741; Fork head related protein like B; Forkhead box P1; Forkhead box protein P1; 12CC4; foxp1; FOXP1_MOUSE; FOX P1; FOXP 1; Glutamine rich factor 1; hFKH1B; HSPC215; MGC12942; MGC88572; MGC99551; QRF 1; QRF1.
Research Area	Tumour  Epigenetics
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	15E2
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:1000-2000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:50-200) （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	79kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human FOXP1 protein, around C-terminal 150aa
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Function: Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development. Subunit: Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Subcellular Location: Nucleus. Tissue Specificity: Highest expression in the lung, brain, and spleen. Lower expression in heart, skeletal muscle, kidney, small intestine (isoform 3 not present) and liver. Similarity: Contains 1 C2H2-type zinc finger. Contains 1 fork-head DNA-binding domain. SWISS: Q9H334 Gene ID: 27086 Database links: Entrez Gene: 27086 Human Entrez Gene: 108655 Mouse Entrez Gene: 297480 Rat SwissProt: Q9H334 Human SwissProt: P58462 Mouse SwissProt: Q498D1 Rat
Product Picture	Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:2000 Primary ab incubation condition: 2 hours at room temperature Secondary ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: 1: HeLa, 2: MCF-7, 3: Daudi Protein loading quantity: 20 μg Exposure time: 60 s Predicted MW: 75kDa Observed MW: 50-95 kDa Tissue: rat colon Section type: Formalin fixed & Paraffin - embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:1000 Primary ab incubation condition: 1 hour at room temperature Secondary ab: Anti-Rabbit and Mouse Polymer HRP Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-52078R Tissue: mouse colon Section type: Formalin fixed & Paraffin - embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:1000 Primary ab incubation condition: 1 hour at room temperature Secondary ab: Anti-Rabbit and Mouse Polymer HRP Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-52078R Tissue: human colon Section type: Formalin fixed & Paraffin - embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:1000 Primary ab incubation condition: 1 hour at room temperature Secondary ab: Anti-Rabbit and Mouse Polymer HRP Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-52078R Tissue: human colon carcinoma Section type: Formalin fixed & Paraffin - embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:1000 Primary ab incubation condition: 1 hour at room temperature Secondary ab: Anti-Rabbit and Mouse Polymer HRP Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-52078R

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