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Product Name Gastric Mucin-6/MUC6 Chinese Name 粘蛋白6重组兔单克隆抗体 Alias Gastric mucin 6 ; Gastric Mucin ;MUC 6 ; MUC-6 ; Muc6 ; MUC6 Fragment ; MUC6 mucin ; MUC6 mucin Fragment ; MUC6_HUMAN ; Mucin 6 ; Mucin 6 gastric ; Mucin 6 oligomeric mucus/gel forming ; Mucin glycoprotein Fragment ; Mucin-6 ; Secretory mucin MUC6 Fragment . Immunogen Species Rabbit Clonality Monoclonal Clone NO. C8A2 React Species (predicted: Human, ) Applications
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 257kDa Cellular localization Secretory protein Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MUC-6 Lsotype IgG Purification affinity purified by Protein A Buffer Solution PBS, Glycerol, BSA Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. [provided by RefSeq, Dec 2016]
Function:
May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Play an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.
Post-translational modifications:
O-glycosylated.
Similarity:
Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 TIL (trypsin inhibitory-like) domain. Contains 3 VWFD domains.
SWISS:
Q6W4X9
Gene ID:
4588
Database links:
- Entrez Gene: 4588 Human
Entrez Gene: 353328 Mouse
Omim: 158374 Human
SwissProt: Q6W4X9 Human
SwissProt: Q80T03 Mouse
Unigene: 528432 Human
Unigene: 246621 Mouse
Unigene: 92457 Rat
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