Product Name	HLA-DRB1
Chinese Name	HLA-DRB1重组兔单克隆抗体
Alias	HLA class II histocompatibility antigen, DRB1 beta chain; DRB1_HUMAN; Human leukocyte antigen DRB1 (HLA-DRB1)
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	E4C2
React Species	(predicted: Human, )
Applications	not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	30kDa
Cellular localization	The cell membrane
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HLA-DRB1
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	PBS, Glycerol, BSA
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene. [provided by RefSeq, Jul 2020] Function: A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells Subcellular Location: Cell membrane 3 Publications; Single-pass type I membrane protein Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein Lysosome membrane 2 Publications; Single-pass type I membrane protein Late endosome membrane 2 Publications; Single-pass type I membrane protein Autolysosome membrane Tissue Specificity: Expressed in professional APCs: monocyte/macrophages, dendritic cells and B cells (at protein level) Expressed in thymic epithelial cells (at protein level) SWISS: P01911 Gene ID: 3123

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