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Product Name IKB beta Chinese Name 核因子κB抑制蛋白βRecombinant rabbit monoclonal anti Alias I kappa B beta; I-kappa-B-beta; IkappaBbeta; IKB beta; IkB-B; IkB-beta; IKBB; IKBB_HUMAN; IkBbeta; NF kappa BIB; NF-kappa-B inhibitor beta; NF-kappa-BIB; Nfkbib; Thyroid receptor interacting protein 9; Thyroid receptor-interacting protein 9; TR interacting protein 9; TR-interacting protein 9; TRIP-9; TRIP9. Immunogen Species Rabbit Clonality Monoclonal React Species Human, (predicted: Mouse, ) Applications WB=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 38kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human IKB beta Lsotype IgG Purification affinity purified by Protein A Buffer Solution PBS, Glycerol, BSA Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011].
Function:
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Subunit:
Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Expressed in all tissues examined.
Post-translational modifications:
Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.
Similarity:
Belongs to the NF-kappa-B inhibitor family. Contains 6 ANK repeats.
SWISS:
Q15653
Gene ID:
4793
Database links:Entrez Gene: 4793 Human
Entrez Gene: 18036 Mouse
Omim: 604495 Human
SwissProt: Q15653 Human
SwissProt: Q60778 Mouse
Unigene: 9731 Human
Unigene: 220333 Mouse
Unigene: 8395 Rat
transcriptional regulatory factor(Transcriptin Regulators)Product Picture Sample:
Lane 1: Human Jurkat cell lysates
Lane 2: Human PANC-1 cell lysates
Lane 3: Human HeLa cell lysates
Lane 4: Human THP-1 cell lysates
Lane 5: Human MCF-7 cell lysates
Lane 6: Human Raji cell lysates
Primary: Anti-IKB beta (SLM-60771R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 38 kDa
Observed band size: 46 kDa
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