Product Name	MEK1
Chinese Name	MEK1Recombinant rabbit monoclonal anti
Alias	mitogen activated protein kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK1; Map2k1; MAPKK1; Mek1; MEKK1; Prkmk1; MP2K1_HUMAN.
Research Area	Tumour  Cell biology  immunology  Neurobiology  Signal transduction  Apoptosis  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Monoclonal
React Species	Human, Mouse,
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	43kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MEK1
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	PBS, Glycerol, BSA
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. SWISS: Q02750 Gene ID: 5604 Database links: Entrez Gene: 5604 Human Entrez Gene: 26395 Mouse Entrez Gene: 170851 Rat Omim: 176872 Human SwissProt: Q02750 Human SwissProt: P31938 Mouse SwissProt: Q01986 Rat Unigene: 145442 Human Unigene: 248907 Mouse Unigene: 5850 Rat
Product Picture	Sample: Lane 1: Mouse NIH/3T3 cell lysates Lane 2: Mouse Muscle tissue lysates Lane 3: Mouse Liver tissue lysates Lane 4: Mouse Lung tissue lysates Lane 5: Human HeLa cell lysates Lane 6: Human MDA-MB-231 cell lysates Lane 7: Human A431 cell lysates Lane 8: Human Jurkat cell lysates Primary: Anti-MEK1 (SLM-60744R) at 1/2000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 43 kDa Observed band size: 43 kDa

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