Product Name	TNFRSF12A/CD266
Chinese Name	Tumour坏死因子配体超家族成员12A（CD266）Recombinant rabbit monoclonal anti
Alias	CD 266; CD266; CD266 antigen; TWEAKR; FGF inducible 14; FGF-inducible 14; Fibroblast growth factor inducible immediate early response protein 14; Fibroblast growth factor-inducible immediate-early response protein 14; FN 14; FN14; TNFRSF 12A; TNR12_HUMAN; Tumor necrosis factor receptor superfamily member 12A; TWEAK R; Tweak receptor; Tweak-receptor; TweakR; Type I transmembrane protein Fn 14; Type I transmembrane protein Fn14.
Research Area	Tumour  Cardiovascular  Cell biology  immunology  Signal transduction  Growth factors and hormones  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	2C14
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:300-5000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	11kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TWEAKR
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TWEAK (otherwise known as TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A), is a member of the TNF family and was first described as a weak inducer of apoptosis in some cell types. It is thought to promote angiogenesis and the proliferation of endothelial cells as well as modulating cellular adhesion to matrix proteins. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library. Function : Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. SWISS: Q9NP84 Gene ID: 51330 Database links: Entrez Gene: 51330 Human Entrez Gene: 27279 Mouse Entrez Gene: 302965 Rat SwissProt: Q9NP84 Human SwissProt: Q9CR75 Mouse

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