Product Name	CMA1
Chinese Name	肥大细胞类糜蛋白酶1Recombinant rabbit monoclonal anti
Alias	CMA1_HUMAN; Chymase; EC:3.4.21.39; CYH; CYM; Mast Cell Chymase; Alpha-chymase; Mast cell protease I;
Research Area	Cardiovascular  immunology  Signal transduction  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	R5H9
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:200-1000 IHC-P=1:100-500 IHC-F=1:200-400 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	25kDa
Cellular localization	cytoplasmic Secretory protein
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CMA1
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008] Subcellular Location: Secreted. Cytoplasmic granule. Note=Mast cell granules. Tissue Specificity: Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions. SWISS: P23946 Gene ID: 1215 Database links: Entrez Gene: 1215 Human Entrez Gene: 17228 Mouse SwissProt: P23946 Human SwissProt: P21844 Mouse

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