Product Name	SET
Chinese Name	SET易位蛋白/髓系白血病相关蛋白Recombinant rabbit monoclonal anti
Alias	SET_HUMAN; Protein SET; HLA-DR-associated protein II; Inhibitor of granzyme A-activated DNase (IGAAD); PHAPII; Phosphatase 2A inhibitor I2PP2A (I-2PP2A); Template-activating factor I (TAF-I); 2PP2A; IGAAD; MRD58; TAF-I; I2PP2A; IPP2A2; PHAPII; TAF-IBETA;
Research Area	Tumour  Cell biology  immunology  Chromatin and nuclear signals  Signal transduction  Apoptosis  Cyclin  t-lymphocyte
Immunogen Species	Rabbit
Clonality	Monoclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-2000 IP=1:10-50 IHC-P=1:100-500 ICC=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	32kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human SET protein : C-terminal
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. SWISS: Q01105 Gene ID: 6418 Database links: Entrez Gene: 6418 Human Entrez Gene: 56086 Mouse Entrez Gene: 671392 Mouse Entrez Gene: 307947 Rat SwissProt: Q01105 Human SwissProt: Q9EQU5 Mouse SwissProt: Q63945 Rat

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