Product Name	PIK3R3
Chinese Name	磷脂酰肌醇激酶调节亚单位gammaRecombinant rabbit monoclonal anti
Alias	P55G_HUMAN; Phosphatidylinositol 3-kinase regulatory subunit gamma; PI3-kinase regulatory subunit gamma; PI3K regulatory subunit gamma; PtdIns-3-kinase regulatory subunit gamma; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; PI3-kinase subunit p55-gamma; PtdIns-3-kinase regulatory subunit p55-gamma; p55PIK; p55; p55-GAMMA; phosphoinositide-3-kinase, regulatory subunit 3 (gamma); PI 3 Kinase p55 gamma.
Research Area	Signal transduction
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	6A1
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:1000-5000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:50-200 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	54kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human PI 3 Kinase p55 gamma protein, around 350-460aa
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Function: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Subunit: Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Tissue Specificity: Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Similarity: Belongs to the PI3K p85 subunit family. Contains 2 SH2 domains. SWISS: Q92569 Gene ID: 8503 Database links: Entrez Gene: 8503 Human Entrez Gene: 18710 Mouse Entrez Gene: 60664 Rat Omim: 606076 Human SwissProt: Q92569 Human SwissProt: Q64143 Mouse SwissProt: Q63789 Rat Unigene: 170510 Human Unigene: 253819 Mouse Unigene: 44448 Rat

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