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Product Name ARF6 Chinese Name ADP核糖基化因子6Recombinant rabbit monoclonal anti Alias ADP ribosylation factor 6; ADP ribosylation factor protein 6; ADP-ribosylation factor 6; Small GTPase; AI788669; AW496366; MGC102530; ADP ribosylation factor protein 6; ARF6_HUMAN; DKFZp564M0264; Small GTP binding protein. Research Area Signal transduction Immunogen Species Rabbit Clonality Monoclonal Clone NO. 5H4 React Species (predicted: Human, ) Applications WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-400 ICC=1:100-200 IF=1:100-200 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 20kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen Recombinant human ARF6 protein, full length Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.
Function:
GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development. Contributes to the regulation of dendritic branching and filopodia extension.
Subunit:
Interacts with ARHGAP21, ASAP2, HERC1, PIP5K1C and UACA. Interacts with NCS1/FREQ at the plasma membrane. Interacts with RAB11FIP3 and RAB11FIP4. Interacts with USP6 (via Rab-GAP TBC domain). Interacts with ECM29. Interacts with TBC1D24.
Subcellular Location:
Golgi apparatus. Cell membrane; Lipid-anchor. Endosome membrane; Lipid-anchor. Cell membrane. Cell projection, filopodium membrane; Lipid-anchor. Note=Recruited to the cell membrane in association with CYTH2 and ARL4C.
Similarity:
Belongs to the small GTPase superfamily. Arf family.
SWISS:
P62330
Gene ID:
382
Database links:Entrez Gene: 382 Human
Entrez Gene: 11845 Mouse
Omim: 600464 Human
SwissProt: P26990 Chicken
SwissProt: P62330 Human
SwissProt: P62331 Mouse
Unigene: 525330 Human
Unigene: 719973 Human
Unigene: 27308 Mouse
Unigene: 6993 Rat
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