Product Name	Chk1
Chinese Name	细胞周期检测点激酶1Recombinant rabbit monoclonal anti
Alias	Cell cycle checkpoint kinase; Checkpoint, S. pombe, homolog of, 1; Checkpoint kinase 1; Checkpoint kinase 1 homolog (S. pombe); CHEK 1; CHEK-1; CHEK1; Chk 1; CHK1 checkpoint homolog (S. pombe); EC 2.7.11.1; rad27; Serine/threonine protein kinase Chk1; Serine/threonine-protein kinase CHK1; STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae); C85740; CHK1_HUMAN.
Research Area	Tumour  Chromatin and nuclear signals  Cyclin  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Monoclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	54kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Chk1
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2011]. SWISS: O14757 Gene ID: 1111 Database links: Entrez Gene: 1111 Human Entrez Gene: 12649 Mouse Entrez Gene: 140583 Rat Omim: 603078 Human SwissProt: O14757 Human SwissProt: O35280 Mouse SwissProt: Q91ZN7 Rat Unigene: 24529 Human Unigene: 16753 Mouse Unigene: 33267 Rat
Product Picture	Sample: Lane 1: Human A431 cell lysates Lane 2: Human HeLa cell lysates Lane 3: Human MOLT4 cell lysates Lane 4: Human MCF-7 cell lysates Lane 5: Human U-2 OS cell lysates Primary: Anti-Chk1 (SLM-60743R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54 kDa Observed band size: 50 kDa

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