Product Name	MLH1
Chinese Name	错配修复蛋白1Recombinant rabbit monoclonal anti
Alias	MLH1_HUMAN; DNA mismatch repair protein Mlh1; COCA2; MutL protein homolog 1; FCC2; HNPCC; MLH-1; hMLH1; HNPCC2; MMRCS1;
Research Area	Tumour  immunology  Signal transduction  transcriptional regulatory factor  TumourCell biologyMaker
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	R6E5
React Species	(predicted: Human, )
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	84kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MLH1
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017] Subcellular Location: Nucleus. Tissue Specificity: Colon, lymphocytes, breast, lung, spleen, testis, prostate, thyroid, gall bladder and heart. SWISS: P40692 Gene ID: 4292 Database links: Entrez Gene: 4292 Human SwissProt: P40692 Human
Product Picture	Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:3000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: 1: HCT-116 (Negative control) , 2: Jurkat Protein loading quantity: 20 μg Exposure time: 60 s Predicted MW: 85 kDa Observed MW: 85 kDa

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