Product Name	PRAME
Chinese Name	黑色素瘤优先表达抗原Recombinant rabbit monoclonal anti
Alias	MAPE; Melanoma antigen preferentially expressed in tumors; OIP 4; OIP-4; OIP4; OPA interacting protein 4; Opa interacting protein OIP4; OPA-interacting protein 4; PRAME_HUMAN; Preferentially expressed antigen in melanoma; Preferentially expressed antigen of melanoma; RP23-250F8.3.
Research Area	Tumour  Cell biology  Signal transduction  TumourCell biologyMaker  Epigenetics
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	R1D8
React Species	(predicted: Human, )
Applications	WB=1:500-1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	56kDa
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PRAME
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008] Subcellular Location: Nucleus (Probable). Cell membrane. Tissue Specificity: Expressed in testis. Detected in samples of kidney, brain and skin. SWISS: P78395 Gene ID: 23532 Database links: Entrez Gene: 23532 Human SwissProt: P78395 Human
Product Picture	Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:1000 Primary Ab incubation condition: 4℃ overnight Secondary Ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: 1: Ramos, 2: K562, 3: HeLa, 4: A375 Protein loading quantity: 20 μg Exposure time: 60 s Predicted MW: 58 kDa Observed MW: 58 kDa

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