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Product Name FKBP52 Chinese Name 热休克蛋白56Recombinant rabbit monoclonal anti Alias FKBP4_HUMAN; Peptidyl-prolyl cis-trans isomerase FKBP4; EC:5.2.1.8; FKBP52; PPIase FKBP4; 51 kDa FK506-binding protein (FKBP51); 52 kDa FK506-binding protein (52 kDa FKBP; FKBP-52); 59 kDa immunophilin (p59); FK506-binding protein 4 (FKBP-4); Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; HBI; p52; Hsp56; FKBP51; FKBP59; PPIase; Immunogen Species Rabbit Clonality Monoclonal Clone NO. R1A10 React Species (predicted: Human, Mouse, Rat, ) Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 52kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FKBP52 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
Subcellular Location:
Cytoplasm; cytosol. Nucleus. Cytoplasm; cytoskeleton.
Tissue Specificity:
Widely expressed.
SWISS:
Q02790
Gene ID:
2288
Database links:Entrez Gene: 2288 Human
Entrez Gene: 14228 Mouse
SwissProt: Q02790 Human
SwissProt: P30416 Mouse
Product Picture Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation condition: 2 hours at
room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L
(HRP)
Lysate: 1: HeLa, 2: Jurkat, 3: F9, 4: Rat testis
Protein loading quantity: 20 μg
Exposure time: 30 s
Predicted MW: 52 kDa
Observed MW: 56 kDa
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