Product Name	TYMS
Chinese Name	胸苷酸合成酶Recombinant rabbit monoclonal anti
Alias	Thymidylate synthase; EC 2.1.1.45; HsT422; MGC88736; TS; TSase; OK/SW-cl.29; TMS; TYSY_HUMAN.
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	R2F5
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-2000 ICC=1:50 IF=1:50-100  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TYMS
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017] Subcellular Location: Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane. SWISS: P04818 Gene ID: 7298 Database links: Entrez Gene: 7298 Human Entrez Gene: 22171 Mouse Entrez Gene: 29261 Rat SwissProt: P04818 Human SwissProt: P07607 Mouse SwissProt: P45352 Rat
Product Picture	Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:2000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: 1: HeLa, 2: Jurkat, 3: HepG2, 4: RAW 264.7, 5: C6 Protein loading quantity: 20 μg Exposure time: 60 s Predicted MW: 36 kDa Observed MW: 36 kDa

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