Product Name	Bim
Chinese Name	细胞死亡调解子Recombinant rabbit monoclonal anti
Alias	Bcl-2 interacting mediator of cell death; Bcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death; BCL2L11; BAM; BIM-alpha6; BIM-beta6; BIM-beta7; BimEL; BimL; BOD; B2L11_HUMAN.
Research Area	Cell biology  Neurobiology  Apoptosis  Kinases and Phosphatases  Mitochondrion
Immunogen Species	Rabbit
Clonality	Monoclonal
React Species	Human, Mouse,  (predicted: Rat, )
Applications	WB=1:500-1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22kDa
Cellular localization	cytoplasmic The cell membrane Mitochondrion
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Bim
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq]. Function : Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis. SWISS: O43521 Gene ID: 10018 Database links: Entrez Gene: 10018 Human Entrez Gene: 12125 Mouse Entrez Gene: 64547 Rat Omim: 603827 Human SwissProt: O43521 Human SwissProt: O54918 Mouse SwissProt: O88498 Rat Unigene: 469658 Human Unigene: 141083 Mouse Unigene: 453214 Mouse Unigene: 82709 Rat
Product Picture	Sample: Lane 1: Mouse Spleen tissue lysates Lane 2: Human Raji cell lysates Lane 3: Human MOLT4 cell lysates Primary: Anti-Bim (SLM-60641R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 22 kDa Observed band size: 26 kDa

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