Product Name	STAT5b
Chinese Name	Signal transduction和转录激活因子5bRecombinant rabbit monoclonal anti
Alias	Transcription factor STAT5B; Signal transducer and activator of transcription 5B; STA5B_HUMAN; STAT5.
Research Area	Tumour  Chromatin and nuclear signals  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	12A1
React Species	(predicted: Human, )
Applications	WB=1:1000-2000 IP=1:20-100  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	90kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human STAT5b protein, around 500-600aa
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008] Subunit: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1, NMI and SOCS7. Interacts (via SH2 domain) with INSR. Subcellular Location: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. Post-translational modifications: Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphoryation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway. Similarity: Belongs to the transcription factor STAT family. Contains 1 SH2 domain. SWISS: P51692 Gene ID: 6777 Database links: Entrez Gene: 6777 Human Entrez Gene: 20851 Mouse Entrez Gene: 25126 Rat Omim: 604260 Human SwissProt: P51692 Human SwissProt: P42232 Mouse SwissProt: P52632 Rat Unigene: 595276 Human Unigene: 34064 Mouse Unigene: 54486 Rat
Product Picture	Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:1000 Primary ab incubation condition: 2 hours at room temperature Secondary ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: HeLa, K562, PC-12, A20 Protein loading quantity: 20 μg Exposure time: 10 s Predicted MW: 90 kDa Observed MW: 90 kDa

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