Product Name	[KO validated anti] N-Cadherin
Chinese Name	N-钙粘附分子抗体
Alias	Cadherin 2; Cadherin 2 N cadherin neuronal; Cadherin 2 type 1; Cadherin 2 type 1 N cadherin neuronal; cadherin 2 type 1 N-cadherin neuronal; Cadherin2; Calcium dependent adhesion protein neuronal; CD325; CD325 antigen; CDH2; CDHN; CDw325; CDw325 antigen; N cadherin 1; NCAD; Neural Cadherin; Neural Cadherin.
literatures	Specific References  (1)     |     SL55138R has been referenced in 1 publications. [IF=3.388] Liu H et al. Circular RNA has_circ_0003204 inhibits oxLDL-induced vascular endothelial cell proliferation and angiogenesis. Cell Signal. 2020 Jun;70:109595.  WB ;  human.   PubMed:32151659
Research Area	Tumour  Cell biology  immunology  Kinases and Phosphatases  Cell adhesion molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, )
Applications	WB=1:500-1000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	97/99kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human N-Cadherin: 750-850-905
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Subcellular Location: Cell membrane. Similarity: Contains 5 cadherin domains. SWISS: P19022 Gene ID: 1000 Database links: Entrez Gene: 1000 Human Entrez Gene: 281062 Cow Entrez Gene: 12558 Mouse Entrez Gene: 83501 Rat SwissProt: P19022 Human SwissProt: P15116 Mouse SwissProt: Q9Z1Y3 Rat 细胞粘附蛋白（Call Adhesion Protein） N-钙粘附分子属于依赖钙离子的细胞间glycoprotein粘附分子的一部分,主要是参与细胞间同源性粘附,调控和介导细胞间相互反应。
Product Picture	Sample: Lane 1: Hela (Human) Cell Lysate at 25 ug Lane 2: N-Cadherin knockout (KO) HeLa (Human) Cell Lysate at 25 ug Primary: Anti-N-Cadherin (SL55138R) at 1/1000 dilution Secondary: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution Predicted band size: 130 kD Observed band size: 135 kD Sample: Lane 1: Heart (Mouse) Lysate at 40 ug Lane 2: A549 (Human) Cell Lysate at 30 ug Primary: Anti-N-Cadherin (SL55138R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 130 kD Observed band size: 130 kD

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