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Product Name LDLR Chinese Name 低密度Lipoprotein受体单克隆抗体 Alias LDLR_HUMAN; Low-density lipoprotein receptor; LDL receptor; FH; FHC; FHCL1; LDLCQ2; low density lipoprotein receptor; Immunogen Species Mouse Clonality Monoclonal Applications
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 92kDa Cellular localization The nucleus cytoplasmic Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human LDL-R Lsotype IgG2a, κ Purification affinity purified by Protein G Buffer Solution PBS, Glycerol, BSA Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2022]
Function:
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
Subunit:
Interacts with LDLRAP1. Interacts with SNX17. Interacts with HCV E1/E2 heterodimer. Interacts with HIV-1 Tat.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Note=Found distributed from the plasma membrane to intracellular compartments.
Tissue Specificity:
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
Post-translational modifications:
N- and O-glycosylated. Ubiquitinated by MYLIP leading to degradation.
Similarity:
Belongs to the LDLR family. Contains 3 EGF-like domains. Contains 7 LDL-receptor class A domains. Contains 6 LDL-receptor class B repeats.
SWISS:
P01130
Gene ID:
3949
Database links:Entrez Gene: 3949 Human
Entrez Gene: 16835 Mouse
Omim: 606945 Human
SwissProt: P01130 Human
SwissProt: P35951 Mouse
Unigene: 213289 Human
Unigene: 728190 Human
Unigene: 3213 Mouse
Unigene: 10483 Rat
低密度Lipoprotein受体 LDLR是一种存在于细胞表面的、可识别多种配体的Lipoprotein受体,在体内对于富含甘油三酯的Lipoprotein代谢非常重要;
LDL R目前主要用于代谢及Tumour方面的研究。Product Picture Sample:
Lane 1: Human MCF-7 cell lysates
Lane 2: Human HeLa cell lysates
Lane 3: Human HepG2 cell lysates
Lane 4: Human Raji cell lysates
Primary: Anti-LDLR (SLM-60756M) at 1/20000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 92 kDa
Observed band size: 130 kDa
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