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Product Name HDAC3 Chinese Name 组蛋白去乙酰化酶3单克隆抗体 Alias RPD3 2; RPD3-2; HD 3; HD3; HDAC 3; Histone deacetylase 3 (HD3) (RPD3-2); histone deacetylase 3; RPD 3; RPD3; SMAP 45; SMAP-45; SMAP45; HDAC3_HUMAN Research Area Tumour Cell biology Developmental biology transcriptional regulatory factor Epigenetics Immunogen Species Mouse Clonality Monoclonal React Species (predicted: Human, Mouse, Rat, ) Applications WB=1:500 IHC-P=1:100-500 ICC=1:50 IF=1:50 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 47kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human HDAC3 Lsotype IgG2b, Kappa Purification affinity purified by Protein G Buffer Solution PBS, Glycerol, BSA Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008].
SWISS:
O15379
Gene ID:
8841
Database links:
Entrez Gene: 8841 Human
Entrez Gene: 15183 Mouse
Omim: 605166 Human
SwissProt: O15379 Human
SwissProt: O88895 Mouse
Unigene: 519632 Human
Unigene: 20521 Mouse
Unigene: 17284 Rat
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