Product Name	TMPRSS2
Chinese Name	丝氨酸蛋白酶10抗体
Alias	Epitheliasin; PRSS10; Serine protease 10; TMPRSS2; TMPRSS2 ERG FUSION GENE, INCLUDED; TMPRSS2 ETV1 FUSION GENE, INCLUDED; TMPS2_HUMAN; Transmembrane protease serine 2 catalytic chain; Transmembrane protease, serine 2; Transmembrane protease, serine 2, EC 3.4.219; Transmembrane protease, serine 2, EC 3.4.219; D16Ertd61e.
Research Area	Tumour  Cell biology  Neurobiology  Kinases and Phosphatases  TumourCell biologyMaker
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	54kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human TMPRSS2 protein: 108-492/492 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Variants ProteinsPrimary AntibodiesELISAsAntibody ArraysActivity Assays ProteinsAntibodiesAssaysGenesshRNAPrimersCRISPRLentiviral Particles CRISPR Knockout KitsgRNAKO PoolsiPSC SNV CloneFree Bioinformatics Tools C. elegans TransgenicsZebrafish Genome EditingHumanized animal models Aliases for TMPRSS2 Gene Aliases for TMPRSS2 Gene GeneCards Symbol: TMPRSS2 2 Transmembrane Serine Protease 2 2 3 5 PRSS10 2 3 4 5 Transmembrane Protease, Serine 2 2 3 Transmembrane Protease Serine 2 3 4 Serine Protease 10 3 4 EC 3.4.21.109 48 Epitheliasin 3 EC 3.4.21.- 4 EC 3.4.21 48 External Ids for TMPRSS2 Gene HGNC: 11876 NCBI Entrez Gene: 7113 Ensembl: ENSG00000184012 OMIM®: 602060 UniProtKB/Swiss-Prot: O15393 Previous GeneCards Identifiers for TMPRSS2 Gene GC21M039410 GC21M041757 GC21M041756 GC21M041750 GC21M042836 GC21M028305 Summaries for TMPRSS2 Gene Entrez Gene Summary for TMPRSS2 Gene This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020] SWISS: O15393 Gene ID: 7113 Database links: Entrez Gene: 7113 Human Entrez Gene: 50528 Mouse Entrez Gene: 156435 Rat Omim: 602060 Human SwissProt: O15393 Human SwissProt: Q9JIQ8 Mouse Unigene: 439309 Human Unigene: 276145 Mouse Unigene: 81082 Rat
Product Picture	Sample: Lane 1: Human HepG2 cell lysates Lane 2: Human HeLa cell lysates Primary: Anti-TMPRSS2 (SL41361R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54 kDa Observed band size: 58 kDa Measured by its binding ability in a indirect ELISA. Immobilized Human TMPRSS2 protein, His Tag (Cat. SL41361P) at 2 μg/mL (100 μL/well) can bind  Rabbit Anti-Human TMPRSS2 Antibody, the EC50 is 118.5 ng/mL.

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