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Product Name RNASE4 Chinese Name 核糖核酸酶4抗体 Alias RAB1; Ribonuclease 4; Ribonuclease A B1; Ribonuclease, RNase A family, 4; RNAS4_HUMAN; RNase 4; RNS4. Research Area Tumour Cardiovascular Cell biology Signal transduction vascular endothelial cell Cytoskeleton Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Mouse, Rat, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 14kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse RNASE4: 91-190/148 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013].
Function:
This RNase has marked specificity towards the 3' side of uridine nucleotides.
Subcellular Location:
Secreted.
Similarity:
Belongs to the pancreatic ribonuclease family.
SWISS:
Q9JJH1
Gene ID:
58809
Database links:Entrez Gene: 465205 Chimpanzee
Entrez Gene: 6038 Human
Entrez Gene: 58809 Mouse
Entrez Gene: 100174757 Orangutan
Omim: 601030 Human
SwissProt: Q8HZQ0 Chimpanzee
SwissProt: P34096 Human
SwissProt: Q9JJH1 Mouse
SwissProt: Q5NVS4 Orangutan
Unigene: 730830 Human
Unigene: 202665 Mouse
Unigene: 1742 Rat
Product Picture Paraformaldehyde-fixed, paraffin embedded (rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (RNASE4) Polyclonal Antibody, Unconjugated (SL25205R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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