Product Name	MMP3
Chinese Name	基质金属蛋白酶3单克隆抗体
Alias	MMP3_HUMAN; Stromelysin-1; EC:3.4.24.17; STMY1; SL-1; SL 1; SL1; Matrix metalloproteinase-3 (MMP-3); MMP-3; MMP 3; Transin-1;
Research Area	Tumour
Immunogen Species	Mouse
Clonality	Monoclonal
React Species	Human,
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	52kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human MMP-3 protein: 18-477/477
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]. Function: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. Subcellular Location: Secreted, extracellular space, extracellular matrix (Probable). Similarity: Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains. SWISS: P08254 Gene ID: 4314 Database links: Entrez Gene: 4314 Human Entrez Gene: 17392 Mouse Entrez Gene: 171045 Rat Omim: 185250 Human SwissProt: P08254 Human SwissProt: P28862 Mouse SwissProt: P03957 Rat Unigene: 375129 Human Synthesis and Degradation（Synthesis and Degradation） 基质金属蛋白酶(matrix metalloproteinases, MMPs)是一族依赖锌离子而降解各种Extracellular matrix的蛋白酶，亦称IV型胶原酶或称明胶酶A，其主要功能为降解IV型胶原，因而它在Tumour细胞突破基底膜屏障和浸润转移中起重要作用。 MMP3目前主要用于各种恶性Tumour(如乳腺癌、胃肠道癌、卵巢癌、膀胱癌等)中的基底膜检测与Tumour转移浸润的研究。
Product Picture	Sample: Lane 1: Recombinant human MMP-3 protein Primary: Anti-MMP3 (SLM-43017M) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 52 kDa Observed band size: 60 kDa

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