Rabbit Anti-KLF4 antibody
Endothelial Kruppel like zinc finger protein; EZF; GKLF; KLF; Kruppel like factor 4 (Epithelial zinc finger protein EZF) (Gut enriched Krueppel like factor); Kruppel like factor 4 (gut); Krueppel-like factor 4;EZF;GKLF;KLF 4;KLF-4;Krueppel like factor 4;
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Product Name KLF4 Chinese Name 肠道内富含的Kruppel样因子/上皮Zinc finger protein4抗体 Alias Endothelial Kruppel like zinc finger protein; EZF; GKLF; KLF; Kruppel like factor 4 (Epithelial zinc finger protein EZF) (Gut enriched Krueppel like factor); Kruppel like factor 4 (gut); Krueppel-like factor 4;EZF;GKLF;KLF 4;KLF-4;Krueppel like factor 4; KLF4_HUMAN. Research Area Tumour Cell biology Signal transduction Stem cells Cyclin transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, ) Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 56kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human KLF4: 1-100/513 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail KLF4 is a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene. It binds the CACCC core sequence. KLF4 may be involved in the differentiation of epithelial cells and may also function in the development of the skeleton and kidney. KLF4 also has roles as both an oncogene and a tumor suppressor.
Function:
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
Subunit:
Interacts with POU5F1/OCT4 and SOX2. Interacts with MUC1 (via the C-terminal domain).
Subcellular Location:
Nucleus.
Post-translational modifications:
Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
SWISS:
O43474
Gene ID:
9314
Database links:Entrez Gene: 9314 Human
Entrez Gene: 16600 Mouse
Omim: 602253 Human
SwissProt: O43474 Human
SwissProt: Q60793 Mouse
Unigene: 376206 Human
Unigene: 4325 Mouse
Klf4（原称GKLF）调节体外細胞的增生与分化，有学者认为：KLF4可能参与消化系统Tumour的发生及发展过程，多表达与结肠。又称：上皮锌指转录因子（上皮Zinc finger protein）Surface skin layer zinc finger protein。Product Picture 
Sample:
Lane 1: Mouse Small intestine Lysates
Lane 2: Mouse Stomach Lysates
Lane 3: Rat Skin Lysates
Lane 4: Human A431 cell Lysates
Primary: Anti-KLF4 (SL24533R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 56kDa
Observed band size: 56kDa
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