Product Name	CD93
Chinese Name	CD93抗体
Alias	C1qrp; Complement component C1q receptor; C1q/MBL/SPA receptor; C1qR(p); C1qr1; C1qRp; CD93 antigen; CD93 molecule; CDw93; Complement component 1 q subcomponent receptor 1; Complement component C1q receptor; dJ737E23.1; ECSM3; Ly68; Matrix remodeling associated protein 4; MXRA4.
Research Area	immunology  Cell adhesion molecule  Cell Surface Molecule  glycoprotein  Cell type markers
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	70kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD93: 601-652/652
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008]. Function: Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. Subunit: Interacts with HCV core protein. Interacts with C1QBP; the association may represent a cell surface C1q receptor. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin. Post-translational modifications: N- and O-glycosylated. Similarity: Contains 1 C-type lectin domain. Contains 5 EGF-like domains. SWISS: Q9NPY3 Gene ID: 22918 Database links: Entrez Gene: 22918 Human Entrez Gene: 17064 Mouse Entrez Gene: 84398 Rat Omim: 120577 Human SwissProt: Q9NPY3 Human SwissProt: O89103 Mouse SwissProt: Q9ET61 Rat Unigene: 97199 Human Unigene: 681 Mouse Unigene: 162695 Rat
Product Picture	Blank control:HUVEC. Primary Antibody (green line): Rabbit Anti-CD93 antibody (SL2474R) Dilution: 1ug/Test; Secondary Antibody (white blue line) : Goat anti-rabbit IgG-AF488 Dilution: 0.5ug/Test. Isotype control（orange line）：Normal Rabbit IgG Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed. Blank control(blue): U937(fixed with 2% paraformaldehyde (10 min)). Primary Antibody: Rabbit Anti-CD93 antibody(SL2474R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.

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