Product Name	Phospho-PTPN11 (Tyr511)
Chinese Name	磷酸化蛋白酪氨酸磷酸酶2抗体
Alias	PTN11_HUMAN; Tyrosine-protein phosphatase non-receptor type 11; PTP2C; SHPTP2; EC:3.1.3.48; Protein-tyrosine phosphatase 1D (PTP-1D); Protein-tyrosine phosphatase 2C (PTP-2C); SH-PTP2 (SHP-2; Shp2); SH-PTP3; protein tyrosine phosphatase non-receptor type 11; CFC; NS1; JMML; BPTP3; PTP2C; METCDS;
Product Type	Phosphorylated anti
Research Area	Tumour  immunology  Neurobiology  Signal transduction  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Pig, Cow, Rabbit, Zebrafish, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:400-800 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	68kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human PTPN11 around the phosphorylation site of Tyr511: AQ(p-Y)RF
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non transmembrane PTP, designated SHPTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SHPTP2 (also designated PTP1D and Syp), has been identified. SHP2 is a protein tyrosine phosphatase that is widely expressed and plays a regulatory role in various cell SWISS: Q06124 Gene ID: 5781 Database links: Entrez Gene: 5781 Human Entrez Gene: 19247 Mouse Entrez Gene: 25622 Rat Omim: 176876 Human SwissProt: Q06124 Human SwissProt: P35235 Mouse SwissProt: P41499 Rat Unigene: 506852 Human Unigene: 474046 Mouse Unigene: 8681 Mouse Unigene: 98209 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Phospho-PTPN11(Tyr511)) Polyclonal Antibody, Unconjugated (SL39021R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Phospho-PTPN11(Tyr511)) Polyclonal Antibody, Unconjugated (SL39021R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Measured by its binding ability in a indirect ELISA. Immobilized Human phospho-PTPN11 protein, His Tag (Cat. SL39021P) at 2 μg/mL (100 μL/well) can bind  Rabbit Anti-Human phospho-PTPN11 Antibody, the EC50 is 10715 ng/mL.

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