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Product Name AMPK alpha-1 Chinese Name 腺苷单磷酸活化蛋白激酶α1抗体 Alias AMPK alpha-1; 5 AMP activated protein kinase alpha 1catalytic subunit; 5 AMP activated protein kinase catalytic alpha 1 chain; 5' AMP activated protein kinase catalytic subunit alpha 1; AAPK1; acetyl CoA carboxylase kinase; AI194361; AI450832; AL024255; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase, catalytic, alpha -1; AMPK 1; AMPK alpha 1 chain; AMPK; AMPK1; AMPKa1; AMPKalpha1; C130083N04Rik; cb116; EC 2.7.11.1; HMG CoA reductase kinase;hormone sensitive lipase kinase; im:7154392; kinase AMPK alpha1; MGC33776; MGC57364; PRKAA 1; PRKAA1; Protein kinase AMP activated alpha 1 catalytic subunit; SNF1-like protein AMPK; wu:fa94c10; AAPK1_HUMAN; AMPKα1; AMPK α1; AMPKα 1; AMPK α 1; AMPK AMPK-α1; AMPK-α-1; α-1; AMPK-a; AMPK a1. Research Area Cell biology Neurobiology Kinases and Phosphatases Alzheimer's Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 64kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen Recombinant human AMPK alpha-1 protein : 1-207/559 Lsotype IgG Purification affinity purified by Protein A Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
SWISS:
Q13131
Gene ID:
5562
Database links:
Entrez Gene: 5562 HumanEntrez Gene: 105787 Mouse
Omim: 602739 Human
SwissProt: Q13131 Human
SwissProt: Q5EG47 Mouse
Unigene: 43322 Human
Unigene: 207004 Mouse
Unigene: 87789 Rat
Product Picture Sample:
Lane 1: Human HUVEC cell lysates
Lane 2: Human SH-SY5Y cell lysates
Primary: Anti-AMPK alpha-1 (SL41337R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 64 kDa
Observed band size: 64 kDa
Measured by its binding ability in a indirect ELISA. Immobilized Human AMPK alpha-1 protein, His Tag (Cat. SL41337P) at 2 μg/mL (100 μL/well) can bind Rabbit Anti-Human AMPK alpha-1 Antibody, the EC50 is 133.7 ng/mL.
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