Product Name	HAVCR2/TIM-3
Chinese Name	Tlymphocyte膜蛋白3(CD366)抗体
Alias	TIM-3; Tim 3; TIM3; TIMD-3; TIMD3; HAVR2_HUMAN; Hepatitis A virus cellular receptor 2; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; CD366;
literatures	Specific References  (1)     |     SL43034R has been referenced in 1 publications. [IF=4.047] Xie Hongbing. et al. Tim-3 downregulation by Toxoplasma gondii infection contributes to decidual dendritic cell dysfunction. PARASITE VECTOR. 2022 Dec;15(1):1-17  WB ;  Human.   PubMed:36303229
Research Area	Cell biology  immunology  lymphocyte  t-lymphocyte  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	29kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human TIM-3 protein: 22-200/301
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011] SWISS: Q8TDQ0 Gene ID: 84868
Product Picture	Sample: Lane 1: Mouse Spleen tissue lysates Lane 2: Mouse Lymph node tissue lysates Lane 3: Mouse Lung tissue lysates Primary: Anti-HAVCR2 (SL43034R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 29 kDa Observed band size: 47 kDa Measured by its binding ability in a indirect ELISA. Immobilized Human TIM-3 protein, HisTag (Cat. SL43034P) at 2 μg/mL (100 μL/well) can bind Rabbit Anti-Human HAVCR2 Antibody, the EC50 is 959.2 ng/mL. Measured by its binding ability in a indirect ELISA. Immobilized Human TIM-3 protein, His Tag (Cat. SL43034P) at 2 μg/mL (100 μL/well) can bind  Rabbit Anti-Human HAVCR2 Antibody, the EC50 is 533.1 ng/mL.

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