Product Name	prox1
Chinese Name	prox-1抗体
Alias	Homeobox prospero like protein; Homeobox prospero like protein PROX1; Prospero related homeobox 1;prox-1; PROX 1.
Research Area	Cardiovascular  immunology  Neurobiology  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	81kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human prox1: 301-400/737
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Prox1 is a prospero-related homeobox gene. Its expression pattern suggests it has a role in a variety of embryonic tissues and may play a fundamental role in early development of the CNS. It may regulate gene expression and the development of postmitotic undifferentiated young neurons. Subcellular Location : Nucleus. Tissue Specificity: Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas. SWISS: Q92786 Gene ID: 5629 Database links: Entrez Gene: 395802 Chicken Entrez Gene: 5629 Human Entrez Gene: 19130 Mouse Entrez Gene: 305066 Rat Entrez Gene: 399348 Xenopus laevis Entrez Gene: 30679 Zebrafish Omim: 601546 Human SwissProt: Q91018 Chicken SwissProt: Q92786 Human SwissProt: P48437 Mouse Unigene: 741808 Human Unigene: 744931 Human Unigene: 132579 Mouse Unigene: 392678 Mouse Unigene: 26557 Rat prox-1主要表达于晶状体、心脏、肝脏、胰腺和神经系统等的非endothelial cells，在成人正常组织、胚胎淋巴管endothelial cells或Tumour组织的淋巴endothelial cells上也可检测到。移除prox-1基因后，胚胎发育时原始静脉endothelial cells生成淋巴管过程被阻断，表明prox-1是淋巴管生成最基本的调控因子.
Product Picture	Paraformaldehyde-fixed, paraffin embedded (human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (prox1) Polyclonal Antibody, Unconjugated (SL25103R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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