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Product Name MTCH1 Chinese Name Mitochondrion载体同源物1抗体 Alias Cell proliferation inducing protein 60; CGI-64; CGI64; Mitochondrial carrier homolog 1; Mitocondrial Carrier Homolog 1; MTCH 1; MTCH1_HUMAN; Presenilin Associated Protein; Presenilin-associated protein; PSAP. Research Area Cell biology Neurobiology Signal transduction Apoptosis Mitochondrion Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Pig, Guinea Pig, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 42kDa Cellular localization cytoplasmic The cell membrane Mitochondrion Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MTCH1: 1-100/389 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Oct 2012]
Function:
Potential mitochondrial transporter. May play a role in apoptosis.
Subunit:
Interacts with PSEN1.
Subcellular Location:
Mitochondrion inner membrane; Multi-pass membrane protein (Potential).
Tissue Specificity:
Widely expressed with a predominant expression in brain.
Similarity:
Belongs to the mitochondrial carrier family.
Contains 2 Solcar repeats.
SWISS:
Q9NZJ7
Gene ID:
23787
Database links:Entrez Gene: 23787 Human
Omim: 610449 Human
SwissProt: Q9NZJ7 Human
Unigene: 485262 Human
Product Picture Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MTCH1) Polyclonal Antibody, Unconjugated (SL23546R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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