Product Name	ZO-1, PerCP-Cy5.5 conjugated
Chinese Name	PerCP-Cy5.标记的胞质紧密粘连蛋白1/闭锁小带蛋白1抗体
Alias	ZO1_HUMAN; Tight junction protein ZO-1; TJP1; Tight junction protein 1; Zona occludens protein 1; Zonula occludens protein 1;
Research Area	Cell biology  immunology  Signal transduction  Cell adhesion molecule  Cell Surface Molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Guinea Pig, )
Applications	Flow-Cyt=1ul/Test  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	191kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ZO-1: 1551-1702/1733
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300.
Storage	Store at 2-8℃. Protect from light. Avoid freezing.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] SWISS: Q07157 Gene ID: 7082 Database links: Entrez Gene: 7082 Human Entrez Gene: 21872 Mouse Omim: 601009 Human SwissProt: Q07157 Human SwissProt: P39447 Mouse Unigene: 510833 Human Unigene: 4342 Mouse

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