Product Name	USP34
Chinese Name	Ubiquitin特异性肽酶 34抗体
Alias	Deubiquitinating enzyme 34 ; FLJ43910 ; KIAA0570 ; KIAA0729 ; MGC104459 ; Ubiquitin carboxyl terminal hydrolase 34 ; Ubiquitin carboxyl-terminal hydrolase 34 ; Ubiquitin specific processing protease 34 ; Ubiquitin specific protease 34 ; Ubiquitin thioesterase 34 ; Ubiquitin thiolesterase 34 ; Ubiquitin-specific-processing protease 34 ; UBP34_HUMAN ; USP 34 ; Usp34 ;
Research Area	Cell biology  Chromatin and nuclear signals  Epigenetics  Ubiquitin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, )
Applications	IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	404kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human USP34
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	PBS containing 50% glycerol, and 0.02% sodium azide.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Enables cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Involved in positive regulation of canonical Wnt signaling pathway and protein K48-linked deubiquitination. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Function: Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Subunit: Interacts with AXIN1 and AXIN2. Tissue Specificity: Expressed in brain at low level. SWISS: Q70CQ2 Gene ID: 9736 Database links: Entrez Gene: 421193 Chicken Entrez Gene: 534067 Cow Entrez Gene: 474608 Dog Entrez Gene: 100064939 Horse Entrez Gene: 9736 Human Entrez Gene: 360989 Rat SwissProt: Q70CQ2 Human Unigene: 644708 Human
Product Picture	Paraformaldehyde-fixed, paraffin embedded (human breast carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (USP34) Polyclonal Antibody, Unconjugated (SL34315R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (human esophagus); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (USP34) Polyclonal Antibody, Unconjugated (SL34315R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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