Product Name	PGII
Chinese Name	胃蛋白酶原C单克隆抗体
Alias	PEPC_HUMAN; Gastricsin; EC:3.4.23.3; Pepsinogen C; PEPC; PGC; progastricsin;
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	1B8
React Species	Human,
Applications	not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	42kDa
Cellular localization	Secretory protein
Form	Lyophilized or Liquid
immunogen	Recombinant Human PGII Protein: 17-388/388
Lsotype	IgG2b
Purification	affinity purified by Protein A
Buffer Solution	PBS (ph=7.4)
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq]. Function: Hydrolyzes a variety of proteins. Subcellular Location: Secreted. Similarity: Belongs to the peptidase A1 family. SWISS: P20142 Gene ID: 5225 Database links: Entrez Gene: 5225 Human Entrez Gene: 24864 Rat Omim: 169740 Human SwissProt: P20142 Human SwissProt: P04073 Rat Unigene: 1867 Human Unigene: 9735 Rat 胃蛋白酶原C(PG-C)主要用于胃癌及其癌前病变易感性的关系。

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