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Product Name Human Tau Chinese Name 微管相关蛋白Tau-4单克隆抗体 Alias MAPT; Microtuble-associted protein Tau; AI413597; AW045860; DDPAC; Disinhibition dementia parkinsonism amyotrophy complex; FLJ31424; FTDP 17; FTDP17; G Protein beta 1 gamma 2 subunit interacting factor 1; G protein beta1/gamma2 subunit interacting factor 1; MAPTL; MGC134287; MGC138549; MGC156663; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; Paired helical filament tau; PHF tau; PHF-tau; PPND; pTau; RNPTAU; Tauopathy and respiratory failure, included; 2N4R; microtubule-associated protein tau isoform 2; Isoform Tau-F;TAU_HUMAN. Research Area Cell biology immunology Neurobiology Signal transduction Apoptosis Immunogen Species Mouse Clonality Monoclonal Clone NO. 3E2 React Species (predicted: Human, ) Applications
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 46/79kDa Cellular localization cytoplasmic The cell membrane Form Liquid immunogen Recombinant human Tau-4 protein: 1-441/441 Lsotype IgG1 Purification affinity purified by Protein A Buffer Solution 0.01M PBS(pH7.4) Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
SWISS:
P10636-8
Gene ID:
4137
Database links:
Entrez Gene: 4137 Human
Entrez Gene: 17762 Mouse
Omim: 157140 Human
SwissProt: P10636 Human
SwissProt: P10637 Mouse
Unigene: 101174 Human
Unigene: 1287 Mouse
Unigene: 2455 Rat
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