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Product Name Prostate Specific Antigen Chinese Name 人前列腺特异性抗原单克隆抗体 Alias antigen, prostate-specific; APS; Gamma seminoprotein; Gamma-seminoprotein; hK3; Kallikrein 3; Kallikrein 3, (prostate specific antigen); Kallikrein related peptidase 3; Kallikrein-3; KLK 3; KLK2A1; KLK3; KLK3_HUMAN; P 30 antigen; P-30 antigen; P30 antigen; Prostate Specific Antigen; Prostate-specific antigen; PSA; Semenogelase; Seminin. Research Area Tumour Immunogen Species Mouse Clonality Monoclonal Clone NO. 4C4 React Species (predicted: Human, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 23kDa Cellular localization Secretory protein Form Liquid immunogen Prostate Specific Antigen (PSA) Antigen, Native Lsotype IgG1 Purification affinity purified by Protein A Buffer Solution 0.01M PBS(pH7.4) Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Function:
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Subunit:
Forms heterodimer with SERPINA5.
Subcellular Location:
Secreted.
Tissue Specificity:
Prostate.
Similarity:
Belongs to the peptidase S1 family. Kallikrein subfamily.
Contains 1 peptidase S1 domain.
SWISS:
P07288
Gene ID:
354
Database links:Entrez Gene: 354 Human
Omim: 176820 Human
SwissProt: P07288 Human
Unigene: 171995 Human
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