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Product Name human IL-6 Chinese Name 人白介素6单克隆抗体 Alias Interleukin BSF 2; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; Cytotoxic T cell differentiation factor; Hepatocyte stimulating factor; HGF; HPGF; HSF; Hybridoma growth factor; Hybridoma plasmacytoma growth factor; IFNB2; IL 6; IL6 protein; Interferon beta 2; Interleukin 6 (interferon beta 2); Interleukin 6; Interleukin-6; Interleukin6; IL6_HUMAN. Research Area Tumour Cell biology immunology Neurobiology Growth factors and hormones Immunogen Species Mouse Clonality Monoclonal Clone NO. 5C7K React Species (predicted: Human, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 23kDa Cellular localization Secretory protein Form Liquid Concentration ≥1mg/ml immunogen Recombinant human IL-6 (C-6x His-Tag) Lsotype IgG1 Purification affinity purified by Protein G Buffer Solution 0.01M PBS(pH7.4) with 0.1% Proclin300. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions.
Function:
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
Subcellular Location:
Secreted.
Post-translational modifications:
N- and O-glycosylated.
DISEASE:
Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
Similarity:
Belongs to the IL-6 superfamily.
SWISS:
P05231
Gene ID:
3569
Database links:Entrez Gene: 3569 Human
Entrez Gene: 16193 Mouse
Omim: 147620 Human
SwissProt: P05231 Human
SwissProt: P08505 Mouse
Unigene: 654458 Human
Unigene: 1019 Mouse
Unigene: 9873 Rat
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