Product Name	PIK3R2
Chinese Name	磷脂酰肌醇激酶p85β单克隆抗体
Alias	P85B_HUMAN; Phosphatidylinositol 3-kinase regulatory subunit beta; PI3-kinase regulatory subunit beta; PI3K regulatory subunit beta; PtdIns-3-kinase regulatory subunit beta; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta (PI3-kinase subunit p85-beta; PtdIns-3-kinase regulatory subunit p85-beta); PI 3 Kinase p85 beta; PI 3-Kinase p85β; PI 3-Kinase p85-β; PI 3-Kinase p85 β; PI3 kinase p85 beta subunit; Phosphoinositide 3 kinase regulatory subunit 2 (beta); p85 beta; p85-BETA; P85B; PI3 Kinase p85 Beta;
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	G8A5
React Species	(predicted: Human, Mouse, )
Applications	WB=1:200-1:1000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	82kDa
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG1/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012] SWISS: O00459 Gene ID: 5296 磷脂酰肌醇-3-激酶（PI3K）的调节亚单位，一种磷酸化PtdIns（4,5）P2（磷脂酰肌醇4,5-二磷酸）生成磷脂酰肌醇3,4,5-三磷酸（PIP3）的激酶。PIP3通过将含有PH结构域的蛋白（包括AKT1和PDPK1）招募到The cell membrane上，激活参与细胞生长、存活、增殖、运动和形态的信号级联，发挥关键作用。通过其SH2结构域与活化（磷酸化）蛋白酪氨酸激酶结合，并充当转接器，介导p110催化单元与质膜的结合。间接调节自噬(出版：23604317). 在肝脏代谢超负荷期间，以内质网应激和/或胰岛素依赖的方式促进XBP1亚型2的核易位，因此在葡萄糖耐量改善中发挥作用。
Product Picture	Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:1000 Primary Ab incubation condition:4°C overnight Lysate: 1: LnCap, 2: K562, 3: NIH/3T3, 4: BRL Protein loading quantity: 20 μg Exposure time: 60 s Predicted MW: 85 kDa Observed MW: 85 kDa Tissue: Human colon Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1:100 Primary Ab incubation condition: 1 hour at room temperature Counter stain: Hematoxylin Comment: Color brown is the positive signal for SLM-60360M Tissue: Mouse colon Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1:100 Primary Ab incubation condition: 1 hour at room temperature Counter stain: Hematoxylin Comment: Color brown is the positive signal for SLM-60360M

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