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Product Name SETDB1 Chinese Name Immunogen Species Mouse Clonality Monoclonal Clone NO. H4A4 React Species (predicted: Human, Mouse, Rat, Monkey, ) Applications WB=1:500-1:1000 IHC-P=1:100-500 ICC=1:50 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Cellular localization The nucleus The cell membrane Form Liquid Concentration 1mg/ml Lsotype IgG1/Kappa Purification Affinity purified by Protein G Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail 组蛋白赖氨酸N-甲基转移酶SETDB1是一种由SETDB1基因编码的酶。SETDB1也称为KMT1E或H3K9甲基转移酶ESET。SET结构域是一个高度保守的,约150个氨基酸的基序,与染色质结构的调节有关。它最初被鉴定为果蝇三胸蛋白中存在的一个较大保守区域的一部分,随后在果蝇Su(var)3-9和“zeste增强子”蛋白中被鉴定,并由此衍生出首字母缩略词集。研究表明,SET结构域可能是通过染色质重塑活动调节转录活性或抑制染色质状态的蛋白质的特征。 Product Picture Blocking buffer: 5% NFDM/TBST
Primary ab dilution: 1:1000
Primary ab incubation condition: 2 hours at room temperature
Lysate:1: HeLa, 2: JurKat, 3: NIH/3T3, 4: COS-7, 5: PC-12
Protein loading quantity: 20 μg
Exposure time: 60 s
Predicted MW: 170 kDa
Observed MW: 170 kDa
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