Product Name	Nucleophosim
Chinese Name
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	A7E10
React Species	(predicted: Human, )
Applications	WB=1:1000 ICC=1:50  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG1/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	参与多种细胞过程，如核糖体的生物发生、中心体复制、蛋白质伴随、组蛋白组装、细胞增殖和Tumour抑制因子p53/TP53和ARF的调控。结合核糖体大概是为了驱动核糖体核输出。与核仁核糖核蛋白结构相关并结合单链核酸。作为核心组蛋白H3、H2B和H4的伴随蛋白。刺激无嘌呤/无嘧啶（AP）双链DNA上的APEX1内切酶活性，但抑制AP单链RNA上的APEX1内切酶活性。可能控制核仁内的APEX1内切酶活性，用于修复rDNA上的AP和去除氧化的rRNA分子。与BRCA2协同调控中心体复制。调节中心粒复制：PLK2磷酸化能够触发中心粒复制。

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