Product Name	HDAC3
Chinese Name	组蛋白去乙酰化酶3单克隆抗体
Alias	HDAC3_HUMAN; Histone deacetylase 3; EC:3.5.1.98; HD3; Protein deacetylase HDAC3; EC:3.5.1.; Protein deacylase HDAC3; RPD3-2; SMAP45; SMAP 45; SMAP-45; RPD3; KDAC3;
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	C12C4
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	47kDa
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG2a/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	负责核心组蛋白（H2A、H2B、H3和H4）N端部分和其他一些非组蛋白底物上赖氨酸残基的脱乙酰。组蛋白去乙酰化为表观遗传抑制提供了一个标签，在转录调控、细胞周期进展和发育事件中起着重要作用。组蛋白脱乙酰基酶通过形成大的多蛋白复合物起作用。通过使增强子元件上的H3'Lys-27'（H3K27）去乙酰化，拮抗EP300乙酰转移酶活性和抑制近端基因表达，参与BCL6转录抑制因子的活性
Product Picture	Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:1000 Primary ab incubation condition: 2 hours at room temperature Lysate: HeLa, HepG2, Neuro-2a, EL4.IL-2, BRL Protein loading quantity: 20 μg Exposure time: 10 s Predicted MW: 48 kDa Observed MW: 48 kDa

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