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Product Name BCL6 Immunogen Species Rabbit Clonality Monoclonal Clone NO. C4E12 React Species Human, Applications WB=1:1000-1:5000 IHC-P=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Cellular localization The nucleus Form Liquid Concentration 1mg/ml Lsotype IgG Purification Affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail 转录抑制因子主要用于生发中心(GC)的形成和抗体亲和力的成熟,其作用机制与谱系和生物学功能有关。在基因毒性应激中,p53/TP53依赖性和非依赖性控制GC B细胞的细胞周期阻滞。此外,还可以通过改变选择性NOTCH靶点(如HES5)的NOTCH依赖性转录复合物的组成来控制神经发生,包括去乙酰化酶SIRT1的募集,并导致表观遗传沉默,神经元分化。 Product Picture
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