Product Name	BMP6
Chinese Name	骨形态发生蛋白6Recombinant rabbit monoclonal anti
Alias	Bone Morphogenic Protein 6; Decapentaplegic vegetal related; DVR6; BMP 6; BMP-6; TGFB related vegetal related growth factor; Transforming growth factor beta; Vegetal related (TGFB related) cytokine; Vg related sequence; VGR; VGR1; BMP6_HUMAN.  VGR; VGR1
Research Area	Cell biology  immunology  Growth factors and hormones  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Monoclonal
React Species	Human, Rat,  (predicted: Mouse, )
Applications	WB=1:500-1000 ICC=1:50 IF=1:50  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	56kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human BMP6
Lsotype	IgG/Kappa
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016] Function: Induces cartilage and bone formation. Subunit: Interacts with SOSTDC1. Subcellular Location: Secreted. Tissue Specificity: Expressed in the lung. Low levels seen in the kidney. Similarity: Belongs to the TGF-beta family. SWISS: P22004 Gene ID: 654 Database links: Entrez Gene: 654 Human Entrez Gene: 12161 Mouse Entrez Gene: 25644 Rat Omim: 112266 Human SwissProt: P22004 Human SwissProt: P20722 Mouse SwissProt: Q04906 Rat Unigene: 285671 Human Unigene: 385759 Mouse Unigene: 40476 Rat BMP6具有诱导软骨内骨化,对刺激骨折愈合和异位骨形成的活性的作用，近年来经研究发现，BMP6与肾胚胎和泌尿系统的发育有关，并参与肝脏生长和分化以及角质细胞形成分化和神经组织的发育调控。
Product Picture	Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:1000 Primary ab incubation condition: 2 hours at room temperature Secondary ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: A549, SH-SY5Y, N2a, Rat lung Protein loading quantity: 20 μg Exposure time: 1 s Predicted MW: 42 kDa Observed MW: 42 kDa Cell line: U-2 OS Fixative: 100% Ice-cold methanol Permeabilization: 0.1% TritonX-100 Primary ab dilution: 1:50 Primary incubation condition: 4°C overnight Secondary ab: Goat Anti-Rabbit IgG Nuclear counter stain: DAPI (Blue) Comment: Color green is the positive signal for SLM-60015R Cell line: NIH/3T3 Fixative: 4% Paraformaldehyde Permeabilization: 0.1% TritonX-100 Primary ab dilution: 1:50 Primary incubation condition: 4°C overnight Secondary ab: Goat Anti-Rabbit IgG Nuclear counter stain: DAPI (Blue) Comment: Color green is the positive signal for SLM-60015R SHSY5Y cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (BMP6) monoclonal Antibody, Unconjugated (SLM-60015R) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.

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