Product Name	CD46
Chinese Name	CD46重组兔多克隆抗体
Alias	MCP; CD46 antigen; CD46 molecule; CD46 molecule complement regulatory protein; Complement membrane cofactor protein antibody MCP; Measles virus receptor; Membrane cofactor protein; Membrane cofactor protein precursor; MIC 10; MIC10; TLX; TRA2.10; Trophoblast leucocyte common antigen; Trophoblast lymphocyte cross reactive antigen; Antigen identified by monoclonal antibody TRA 2 10.
Research Area	immunology  glycoprotein
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	4C3
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:1000-5000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD46
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	CD46 is one of the membrane complement regulatory proteins. CD46 possesses C3b-binding and factor I cofactor activities which play important roles in the regulation of the complement activation pathway. CD46 is widely distributed on blood cells, endothelial cells, epithelial cells and tumor cell lines. CD46 exists as many isoforms in a variety of tissues. The antigen has a broad distribution and is present on leukocytes, platelets, endothelial cells, epithelial cells and fibroblasts. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. It is expressed on thymocytes, B cells, monocytes, granulocytes, NK cells, platelets, epithelial and endothelial cells. Function: May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Subcellular Location: Isoform 1: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa. Isoform 2: Secreted (Probable). Tissue Specificity: Present only in testis (at protein level). Post-translational modifications: May be O-glycosylated (By similarity). N-glycosylated. Similarity: Contains 4 Sushi (CCP/SCR) domains. SWISS: P15529 Gene ID: 4179 Database links: Entrez Gene: 17221 Mouse Entrez Gene: 4179 Human Entrez Gene: 29333 Rat Omim: 120920 Human SwissProt: P15529 Human SwissProt: O88174 Mouse SwissProt: Q9Z0M4 Rat Unigene: 510402 Human Unigene: 12884 Mouse Unigene: 163242 Rat
Product Picture	Sample: Lane 1: Hela (Human) Cell Lysate at 30 ug Lane 2: MCF-7 (Human) Cell Lysate at 30 ug Lane 3: Siha (Human) Cell Lysate at 30 ug Primary: Anti-CD46 (SLM-54335R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 56-65 kD Observed band size: 56-65 kD Paraformaldehyde-fixed, paraffin embedded (Human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD46) Monoclonal Antibody, Unconjugated (SLM-54335R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (human gastric); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD46) Monoclonal Antibody, Unconjugated (SLM-54335R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (human gastric carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD46) Monoclonal Antibody, Unconjugated (SLM-54335R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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