Product Name	Uteroglobin
Chinese Name	子宫珠蛋白Recombinant rabbit monoclonal anti
Alias	blastokinin; CC10; CC16; CCPBP; CCSP; Clara cell phospholipid binding protein; Clara cell phospholipid-binding protein; clara cell secretory protein; Clara cell specific 10 kD protein; Clara Cells 10 kDa Secretory Protein; OTTHUMP00000236107; Secretoglobin family 1A member 1; Secretoglobin, family 1A, member 1 (uteroglobin); UG; UGB; UP-1; UP1; Urinary Protein 1; Urine Protein 1; UTER_HUMAN; SCGB1A1; Utg.
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	7G5
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-1000 ICC=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	8kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human Uteroglobin
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Uteroglobin belongs to the family of secretoglobins and is a secreted protein product of nonciliated bronchiolar Clara cells. There is convincing data suggesting it has phospholipase A2 inhibitory activity, as well as, a number of other immunomodulatory features including inhibition of interferon gamma signalling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheral marker of respiratory epithelial injury and bronchial dysfunction. Clara Cell Protein 16 concentrations have been determined in both serum and bronchoalveolar lavage fluid in numerous studies since 1994. In serum, its increase is associated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, in silica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac pleural congestion. Function: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. Subunit: Homodimer; antiparallel disulfide-linked. Subcellular Location: Secreted. Tissue Specificity: Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways). Similarity: Belongs to the secretoglobin family. SWISS: P11684 Gene ID: 7356 Database links: Entrez Gene: 7356 Human Entrez Gene: 22287 Mouse Entrez Gene: 25575 Rat Omim: 192020 Human SwissProt: P11684 Human SwissProt: Q06318 Mouse SwissProt: P17559 Rat Unigene: 523732 Human Unigene: 2258 Mouse Unigene: 2206 Rat
Product Picture	Sample: Lane 1: A431 (Human) Cell Lysate at 30 ug Lane 2: A549 (Human) Cell Lysate at 30 ug Primary: Anti-SCGB1A1/Uteroglobin (SLM-54221R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 10 kD Observed band size: 14 kD

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